what is wrong with him通常是对方看到某个人出现异常而抛出的话。这位人可能说话疯疯癫癫，或者脸上非常不好看。

如果面对第一情况，可答复he is always acting crazy, just ignore him。第二情况的话，请答复 he may be sick, let us offer him some help

1.What is wrong with him?He is sad.be动词的后面接形容词。构成主系表结构。表示某人怎么样…

2.这个句子的同义句为What is the matter with him?He is ill.

3.问某人怎么样也可以说What is his trouble?He is unhappy.在英语学习中要多读多练就会有语感。

my parents with him做主语谓语用单数还是复数？

复数 are 因为 parents 是复数,指的是父母两个人 如果是parent,用单数 is 因为这个时候用的是名次单数,指父亲或母亲(一个人)